KolplaGene in the era of Next Generation Sequencing (NGS)
Kolplagene is here to simplify and democratize a wide range of molecular biology analyses, such as sequencing for oncology tests.
Dr. Bene Fittipaldi | Biotechnologist Alexandre Campos Banari
Precision medicine has found in genetic and molecular analysis tools for prevention, diagnosis, guidance on the risks of developing diseases and better treatment approaches. And all from a small biological sample that allows us to obtain essential information based on genomics.
Adjectivizing the months of the year with color names, such as Pink October, Blue November, Orange December, is one of many actions that seek to raise awareness of the importance of preventive actions in the fight against various types of cancer. Complex as a disease, cancers have been and continue to be a challenge for scientists who seek to understand all their mechanisms of onset and development. DNA sequencing studies, now a tangible reality, promise to change this scenario in favor of science.
Hereditary alterations in certain genes are responsible for up to 10% of cancer cases and, within this context, Next Generation Sequencing (NGS) tests, by making it possible to understand and act on these alterations, are gaining prominence in preventive medicine.
However, for genetic and biomolecular analysis to be successful as a tool for disease prevention, it is necessary to correctly collect and transport the biological sample from which the genetic material will be extracted. There was, however, an obstacle to overcome. Most of the devices used to collect and transport samples require refrigeration to prevent the degradation of nucleic acids (DNA and RNA), which has limited their use, especially in Brazil, where the enormous territorial dimension and logistical shortcomings make the transportation of this material a huge challenge.
To solve this real puzzle, KolplaGene is Kolplast Group’s pioneering response to the market. It has lytic activity, ensuring complete release of nucleic acids into the aqueous solution, allows the pH of the aqueous solution to be maintained, prevents contamination from microbiological sources and prevents complete or partial degradation of the nucleotide chain for up to 30 days at room temperature.
Kolplagene has come to uncomplicate and democratize a wide range of molecular biology analyses, such as sequencing for cancer tests focused on identifying mutations in BRCA1, BRCA2 or unaltered genes, as well as other genomic analyses in the fields of pharmacogenetics, nutrigenetics, microbiota, environmental monitoring and ancestry.
KolplaGene is a milestone in the history not only of the Kolplast Group, but also of Brazil, as it places a Brazilian technology on the world genetic research scene.
